![]() ![]() ![]() Mice with defective Hh signal exhibit a wide spectrum of anomalies, including Vertebral defects, Anal atresia, Cardiovascular anomalies, Tracheoesophageal fistula, Renal dysplasia, and Limb defects, that resemble strikingly the phenotypes observed in VACTERL association in humans. The specificity of these developmental processes is achieved through a tight spatio-temporal regulation of Hh signaling. Hedgehog (Hh) signaling is vital for the patterning and organogenesis of almost every system.
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